I don't even care about the effect first-hand. There are people out there who have DIED because they messed around with drugs. The simple cut and dry question is WHY would you even want to risk it?
Bring me all the local references you want. My money says their heads won't be in the proper place to speak honestly about this topic.
List of celebreties who are dead due to DRUGS:
http://en.wikipedia.org/wiki/List_of...related_causes